That spot has a name in the research, the LI4 point. It sits in the soft web between your thumb and first finger, and it is the most studied pressure point for migraine in the clinical literature.
When we held steady pressure on it, the over-firing nerve started to settle, and the attacks lost their grip.
A 2019 review in the journal Cephalalgia found that LI4 stimulation cut headache intensity in study after study. The catch was always the same.
You cannot hold your own hand for 24 hours a day.
Press it for 60 seconds and you feel it ease. Let go and the nerve winds right back up. To break the loop, the pressure has to be there all the time, even while you sleep.
That was the whole problem worth solving, and it had nothing to do with another drug.